What is ST2 protein?
ST2 protein is the interleukin 33 (IL-33) receptor, whose serum level depends on the biomechanical strain of cardiac myocytes. The aim of this study was to analyse the relationship between soluble ST2 (sST2) level and traditional factors in patients with chronic heart failure.
WHAT IS ST II medical?
ST2 is an interleukin (IL)-1 receptor family member with a functionally active transmembrane isoform (ST2L) and a soluble isoform (sST2) that can be detected in human plasma. ST2 is a receptor for IL-33. IL-33 is a potential mediator of several inflammatory diseases through the ST2L signalling pathway (1).
What is soluble ST2?
The soluble form of ST2 is a decoy receptor that inhibits beneficial cardioprotective effects of IL-33; such inhibition results in cardiac hypertrophy, myocardial fibrosis, and ventricular dysfunction. Measurement of soluble ST2 has utility for assessing heart failure severity and prognosis.
What is ST2 in heart failure?
ST2 is a member of the interleukin-1 receptor family biomarker and circulating soluble ST2 concentrations are believed to reflect cardiovascular stress and fibrosis. Recent studies have demonstrated soluble ST2 to be a strong predictor of cardiovascular outcomes in both chronic and acute heart failure.
What are ILC2 cells?
ILC2 cells, or type 2 innate lymphoid cells are a type of innate lymphoid cell. They are derived from common lymphoid progenitor and belong to the lymphoid lineage. These cells lack antigen specific B or T cell receptor because of the lack of recombination activating gene.
What is a NT Pro BNP blood test?
The NT-proBNP blood test measures brain natriuretic peptide to detect heart failure. If your doctor orders a BNP test, you are probably showing symptoms of heart failure. The test measures a hormone called “brain natriuretic peptide.”
What are lymphoid markers?
Hematopoietic Stem Cells (HSCs) are able to differentiate into cells of two primary lineages, lymphoid and myeloid. Cells of the lymphoid lineage develop during the process of lymphopoiesis and include B Cells, T Cells, Natural Killer (NK) Cells, and Dendritic Cells.
